I can go either way on this stuff, and the answer is different for different people. We use our cars differently and we have different backgrounds.
For my formula car a carb works well, not much is asked of it really. The alternative with a heavier battery, an alternator an all the extra wiring makes little sense. I even enjoy the moment I spend during the first start of the day using the palm of my hand to choke while I reach into the cockpit and hit the start button.
If you don't already have an education in carbs, it doesn't make so much sense for most people to learn all that. That goes at least double for a street car which is much more demanding of it's carb.
Injection can be quite a hill to climb though if you have to learn how to use a computer to even get started.
In the Holley TBI the computer sits inside where the float bowl would go, so it can get rather warm. Good embedded computer chips are specified for high temperature though. The one I am working with is rated from -40F to +302F ( which to me seems to make it perfect for a small block Ford
). This is the temperature of the chip, not the air temp - but you can see it is a rather robust unit compared to what is in your laptop or cell phone...
I have no idea what the parts are used in a Megasquirt though and you might find a rather different answer...
I think the Holley TBI might be a good choice for someone with a pretty standard engine who doesn't look forward to learning a lot about computers or carbs for that matter... Fancy or radical cams, porting or unusual intakes and exhausts might be more difficult for it...